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  • Assessment of Immunoprophyl...
    Sugumar, P; Tikaram, J V; Gatne, M; Chandran, D; Mangamoori, L N; Rangarajan, P N; Srinivasan, V A

    Current trends in biotechnology and pharmacy, 10/2010, Letnik: 4, Številka: 4
    Journal Article

    Use of recombinant Bm95 isolated from an Argentinean strain of Rhiphicephalus microplus A as a vaccine candidate to control the tick infestation in India was investigated. Recombinant Bm95 expressed in yeast, Pichia pastoris. Purified protein blended into a vaccine using aluminium hydroxide as an adjuvant. An adverse effect on the reproduction of ticks was observed in vaccinated animals indicating reduced the environmental contamination and source of infestation indicating its use of Bm95 in the immunological control of ticks in India.