It has been proved that process capability indices provide very efficient measures of the capability of processes from many different perspectives. At the present time, the C pk index is used more than any other index for measuring process capability. However, most existing research works for capability testing have focused on processes with symmetric tolerances, but not for asymmetric tolerances. A lower confidence bound estimates the minimum process capability, conveying critical information regarding product quality, which is essential to quality assurance. The sample size determination, which provides the sample sizes necessary to achieve a desired lower confidence bound, is directly related to the cost of the data collection plan. This paper provides explicit formulas with efficient algorithms to obtain the lower confidence bounds and sample sizes required for specified precision of the estimation on C pk for processes with asymmetric tolerances. A Matlab computer program using a binary search method is developed. For the practitioners to use in their in-plant applications, we tabulate lower confidence bounds for some commonly used capability requirement and the sampling accuracy of C pk for sample sizes determination. A realistic example of forging process is presented to illustrate the applicability of the proposed method.