Cultural landscapes, particularly cities with rich historical and cultural heritage, play a crucial role in bolstering the resilience of local communities. The occurrence of climate change-induced phenomena jeopardizes cultural landscapes, resulting in the deterioration of historical structures, natural landscapes, cultural heritage, the economy, and the livelihoods of residents in these areas. Therefore, adopting a resilient approach is essential for the integrated management of cultural landscapes. This study develops a model for enhancing cultural landscape resilience to climate change in Nishapur, a historical and cultural city in Iran. Through desk studies, factors affecting the resilience of cultural landscapes to climate change were extracted in the context of developing countries. Subsequently, a model was developed based on the frequency of the occurrence of dimensions and indicators. Snowball sampling was used to distribute questionnaires to 310 members of the academic and professional communities in the field. Next, confirmatory factor analysis (CFA) was conducted using IBM SEM-AMOS to analyze the data and measure the reliability and validity of the model. The findings indicate that the driving factors of change, such as changes in livelihood and social issues, historical fabric and physical environment, natural hazards, biodiversity patterns, and management patterns, can significantly affect the resilience of cultural landscapes to climate change. The developed model can contribute to policymaking in various fields, including urban design and planning, economics, sociology, and cultural heritage conservation. This can play a vital role in creating cultural landscapes that are resilient to the increasing impacts of climate change. •A model used to improve cultural landscape (CL) resilience to climate change (CC).•Prioritizing factors that bolster the resilience of CL in the face of CC is imperative.•Management patterns play the most crucial role in developing countries.•Livelihood change and social issues are the next important factors.•Promoting tangible and intangible heritage at historical sites and cultural events is necessary.