Transgenic cultivars expressing delta -endotoxin coding genes of Bacillus thuringiensis are being grown globally on about 12 million hectares this year. Agriculture in India can benefit substantially by adopting transgenic insecticidal cultivars since, in contrast to the world average of 30%, of the total chemical pesticides used in India 75% are employed against insects. No other biological approach, as safe as and yet as effective as the Bt technology is presently known to control agricultural pests. The question at the center stage is to expedite the commercial release of Bt transgenics and also make a parallel effort to devise knowledge-based strategies aimed at achieving longer durability of crop resistance to insect pests. Plant breeders have encountered similar situations in the past for improving crops against insects and other diseases. This article identifies the gap areas where research efforts are needed to develop strategies for enhancing the durability of crop resistance.