This article aims to examine the character of the international relationships of the Czech Republic in R&D in the Key Enabling Technologies (KETs), and in the protection of international industrial property rights. The analysis of the publication activities indicates an increase of the internationalization of the Czech R&D in nanotechnology and to a lesser extent in advanced manufacturing technologies both in an absolute volume and relatively to the overall internalization of the whole Czech R&D system. The R&D related to KETs uses the foreign expertise less than is the overall extent of the R&D international collaboration of the Czech Republic. The traditional Czech R&D partners USA, UK, and Germany dominate in the KETs oriented collaborations. The collaboration in photonics and micro- and nanoelectronic with Japan, in nanotechnology with Malaysia and in advanced materials with Singapore is significantly higher than the overall collaboration with these countries. On the other side it is rather disquieting, that countries with advanced R&D like Austria, Switzerland, the Netherlands and Sweden are underrepresented in the KETs oriented Czech collaborative research. The patent analysis indicates that almost a half of the inventions in which the Czech researchers participated, is co-owned by foreign subjects. This probably relates to a significant number of global corporations or subsidiaries with R&D operating in the Czech Republic. In micro- and nanolelectronics and to a significant extent in photonics more than half of patent applications are co-owned by foreign entities. Most of the patent applications originating from Czech inventors are owned by US subjects. On the other hand the fraction of patent applications which have foreign inventors and are co-owned by Czech subjects is significantly lower in comparison with developed countries.