E-viri
PDF
Recenzirano
Odprti dostop
-
Dabos, L; Jousset, A B; Bonnin, R A; Fortineau, N; Zavala, A; Retailleau, P; Iorga, B I; Naas, T
Antimicrobial agents and chemotherapy, 10/2018, Letnik: 62, Številka: 10Journal Article
OXA-535 is a chromosome-encoded carbapenemase of JAB-1 that shares only 91.3% amino acid sequence identity with OXA-48. Catalytic efficiencies are similar to those of OXA-48 for most β-lactams, except for ertapenem, where a 2,000-fold-higher efficiency was observed with OXA-535. OXA-535 and OXA-436, a plasmid-encoded variant of OXA-535 differing by three amino acids, form a novel cluster of distantly related OXA-48-like carbapenemases. Comparison of and genetic environments suggests that an IS may be responsible for gene mobilization from the chromosome of spp. to plasmids.
