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Hirokawa, Makoto; Sawada, Kenichi; Fujishima, Naohito; Teramura, Masanao; Bessho, Masami; Dan, Kazuo; Tsurumi, Hisashi; Nakao, Shinji; Urabe, Akio; Fujisawa, Shin; Yonemura, Yuji; Kawano, Fumio; Oshimi, Kazuo; Sugimoto, Koichi; Matsuda, Akira; Karasawa, Masamitsu; Arai, Ayako; Komatsu, Norio; Harigae, Hideo; Omine, Mitsuhiro; Ozawa, Keiya; Kurokawa, Mineo
British journal of haematology, June 2015, Letnik: 169, Številka: 6Journal Article
Summary Immunosuppressive therapy has been employed as the initial treatment for acquired chronic pure red cell aplasia (PRCA), such as idiopathic, thymoma‐associated, or large granular lymphocyte (LGL) leukaemia‐associated PRCA, which is thought to be immune‐mediated. To explore the overall long‐term outcome following immunosuppression and to identify the risk factors for death in these disorders, we conducted nationwide surveys in Japan 2004 and 2006, and identified a total of 185 patients with acquired chronic PRCA, including 72 idiopathic, 41 thymoma‐associated and 14 LGL leukaemia‐associated cases of PRCA for whom data was available. The present study evaluated 127 patients with these three subsets of PRCA. The median overall survival has not yet been reached in idiopathic PRCA. The estimated median overall survival times in patients with thymoma‐associated and LGL leukaemia‐associated PRCA were 142·1 and 147·8 months, respectively. Twenty‐two deaths were reported, and the response to induction therapy and relapse of anaemia were found to be associated with death. The major causes of death were infection in seven patients and organ failure in another seven patients. The results suggest that maintenance therapy and the management of infectious complications are crucial for improving the prognosis of chronic PRCA.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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