E-viri
Recenzirano
Odprti dostop
-
Tura, Andrea; Göbl, Christian S.; Franks, Paul W.; Pearson, Ewan R.; Giordano, Giuseppe N.; Ruetten, Hartmut; Dermitzakis, Emmanouil T.; Pedersen, Oluf; De Masi, Federico; Tsirigos, Konstantinos D.; Brunak, Søren; Mahajan, Anubha; McDonald, Timothy J.; Vangipurapu, Jagadish; Cederberg, Henna; Rutters, Femke; Beulens, Joline W.; Allin, Kristine H.; Vestergaard, Henrik; Mari, Andrea; Abdalla, Moustafa; Adragni, Kofi; Arumugam, Manimozhiyan; Atabaki Pasdar, Naeimeh; Baltauss, Tania; Bergstrom, Margit; Beulens, Joline W.; Bianzano, Susaana; Bizzotto, Roberto; Bonneford, Amelie; Brown, Andrew A.; Caiazzo, Robert; Cederberg, Henna; Dale, Matilda; Davtian, David; Dawed, Adem Y.; de Preville, Nathalie; Dekkers, Koen F.; Deshmukh, Harshal A.; Donnelly, Louise; Dutta, Avirup; Elders, Petra J. M.; Engelbrechtsen, Line; Fan, Yong; Fernandez, Juan; Ferrer, Jorge; Forman, Annemette; Franks, Paul W.; Frau, Francesca; Fritsche, Andreas; Froguel, Philippe; Frost, Gary; Groeneveld, Lenka; Gupta, Ramneek; Haid, Mark; Hansen, Torben; Hansen, Tue H.; Hattersley, Andrew T.; Haussler, Ragna; Heggie, Alison J.; Jablonka, Bernd; Johansen, Joachim; Jonsson, Anna; Klintenberg, Maria; Kokkola, Tarja; Koopman, Anitra D. M.; Kurbasic, Azra; Laakso, Markku; Lehr, Thorsten; Loftus, Heather; Lundgaard, Agnete T.; Mahajan, Anubha; Mazzoni, Gianluca; McCarthy, Mark I.; McEvoy, Donna; McVittie, Ian; Musholt, Petra; Nice, Rachel; Pavo, Imre; Pedersen, Helle K.; Perry, Mandy H.; Ramisch, Anna; Rasmussen, Simon; Roderick, Slieker; Rodriquez, Marianne; Ruetten, Hartmut; Schwenk, Jochen M.; Sihinevich, Iryna; Sondertoft, Nadja B.; Thomas, Louise; Thorne, Claire E.; Troll, Martina; Tsirigos, Konstantinos D.; Vangipurapu, Jagadish; van Oort, Sabine; Vogt, Josef K.; Walker, Mark; Wesolowska-Andersen, Agata; Whitcher, Brandon; White, Margaret W.
Diabetes (New York, N.Y.), 09/2021, Letnik: 70, Številka: 9Journal Article
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose IFG, impaired glucose tolerance IGT, or HbA1c indicative of prediabetes IA1c), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control subjects. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, those with IGT showed lower insulin sensitivity, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (P < 0.002). Conversely, those with IA1c showed higher insulin sensitivity and ISRr (P < 0.0001). Among groups with two defects, we similarly found differences in both BCF and insulin sensitivity. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, P < 0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared with the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.