The present study aims to investigate the impact of nanoparticle migration due to Brownian motion and thermophoresis on Ag-MgO/Water hybrid nanofluid natural convection. An enclosure with sinusoidal wavy walls is considered for this investigation; right and cold walls of this enclosure are in constant temperature while the upper and bottom walls are insulated. This simulation follows Buongiorno's mathematical model; Brownian and thermophoresis diffusion of Ag occurs in MgO-Water nanofluid while the diffusion of MgO happens in Ag-water nanofluid. The result indicates that Nu number increments up to 11% by increasing thermophoresis diffusion for both nanoparticles. Also, increasing Brownian diffusion of Ag augments nanoparticle concentration on hot wall, while the accumulation of nanoparticles unifies by incrementing Brownian diffusion of MgO. Display omitted •Ag − MgO/water hybrid nanofluid utilizing Buongiorno's mathematical model.•Nanoparticle accumulates better on the cold wall due to thermophoresis migration.•Nu number increments up to 11% by increasing thermophoresis diffusion.•The accumulation of nanoparticles unifies by augmenting DBMgO.