Time Projection Chambers with C-pads and integrated delay line readout were developed as position sensitive detectors for the Fragment separator at GSI Darmstadt. The main advantages of TPCs are a small amount of matter in the sensitive volume, high spatial resolution, and high tracking efficiency. Working parameters in experimental conditions are presented. Internal spatial resolutions of σ x = 88 μ m and σ y = 38 μ m were achieved. The tracking efficiency dependence on ion beam intensity was studied with 238U beam at 1 GeV/ u energy. Efficiency of more than 99% was achieved up to 40 kHz and over 90% for 250 kHz 238U beam intensity. Different kinds of ions from proton to uranium were measured in many experiments and confirmed the result obtained.