E-viri
Recenzirano
-
Misiura, Maria; Igwe, Kay; Howell, J. Christina; Tannahill, Amber; Brickman, Adam M.; Turner, Jessica A.; Hu, William T.
Alzheimer's & dementia, December 2021, 2021-12-00, Letnik: 17, Številka: S4Journal Article
Background Alzheimer’s disease (AD) is twice as likely to occur in African Americans than in Non‐Hispanic Whites. However, current neuroimaging models of AD do not accurately overlay onto the African American profile of this disease. One variable that could contribute to more accurate modeling is the inclusion of vascular factors into models of AD, as African Americans are more likely to have vascular as well as AD. Functional MRI is a widely used method to measure brain activity in individuals with AD. Connectivity in the form of correlated between regions can be used to determine neurological dysfunction. Fronto‐striatal connectivity, while understudied in AD, has shown to be affected by AD and vascular disease. This study attempts to determine if there are connectivity measures that relate to vascular lesions(White Matter Hyperintensities (WMH)) across the disease spectrum, and whether these relationships are uniform across race. Method We analyzed data from 88 people (54= NC, 34=MCI). We conducted functional connectivity using DPARSFA toolbox with connectivity calculated between the following fronto‐striatal regions within each hemisphere: anterior putamen, middle frontal gyrus, superior frontal gyrus (putamen output regions), pre‐ and postcentral gyri (putamen input regions). To calculate regional white matter hyperintensity we used in‐house code to overlay a regional atlas onto a WMH mask extracted from a T2 weighted FLAIR image, and assigned a score to each individual representing load (0=no WMH in any regions, 1=WMH in 1 or the other region, 2=present in both regions. Result Across race and diagnostic categories, WMH were related negatively to right anterior putamen connectivity to the pre and post central gyri such that as WMH load increased, connectivity also decreased. This relationship continued for connectivity measures between the right anterior putamen and the superior and middle frontal gyri, but only within African Americans. Conclusion Fronto‐striatal connectivity did correlate with regional WMH load in a uniform manner across races for cortical input regions to the putamen, and this relationship extended to Africans Americans within cortical output regions. This relationship was identified across diagnostic categories, and could be useful in studies investigating vascular relationships to AD biomarkers.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.