The aim of this self-paced reading study was to investigate the role of grammatical and context-based gender in assigning an antecedent to a pronoun where the antecedent is an epicene or a bigender noun. In Italian, epicene nouns (e.g., vittima, victim) have grammatical gender, whereas bigender nouns (e.g., assistente, assistant) do not have grammatical gender but instead acquire it from the context in which they occur. We devised three different types of context: incongruent contexts (i.e., contexts containing a gender bias that differed from the grammatical gender of the epicene), congruent contexts (i.e., contexts where the gender bias and grammatical gender coincided), and neutral contexts. In the case of epicenes, pronoun resolution was driven by grammatical gender; in the case of bigenders it was driven by the gender assigned by context. The results are discussed in the light of current models of anaphor resolution.