To mitigate the adverse effects of cavitation on the performance degradation and chemical corrosion of hydraulic machines, a jet hydrofoil physical model based on the structure of a guide vane model of a high-pressure mixed-flow hydraulic turbine was established. A density correction turbulence model based on filters was adopted to numerically simulate the cavitation characteristics on the surface of the jet hydrofoil. The results demonstrate that when the jet speed is 12 m/s and the jet angle is −15°, the scheme exhibits the best cavitation suppression effect among all combinations of jet angles and speeds. Cavities near the jet structure are prematurely collapsed after being pressurized, and the cavitation suppression effect in the low-pressure area at the trailing edge is also satisfactory. The time-averaged bubble volume fraction reaches its minimum at 2.17%, with the time-averaged bubble volume fraction being 27.3% of the prototype hydrofoil. At flow speeds of 2.4 m/s and 7.2 m/s, small-angle jet fluid accumulated will stick to the closed cavities on the surface of the hydrofoil and cause them to rupture, while the jet fluid at the jet angle of 60° and speeds of 7.2 m/s and 12 m/s will directly cut off the bubbles. •DCMFBM model is used to simulate cavitation characteristics on hydrofoil.•Analysis of jet angle and velocity impact on cavitation characteristics.•High-speed jet at small angles most effectively suppresses cavities.