There are several compelling reasons for airlines to consider single pilot operations including economic savings, coping with a shortage of pilots, and automation and artificial intelligence technology advancement. To adequately explore this concept, differing aviation industry views of single pilot operations (SPO), challenges associated with single pilot operations, an overview of current SPO research and options, and conclusions and recommendations are presented. Ultimately, many obstacles to implementation must be overcome including convincing the general public that it safe which may be the biggest challenge of all. However, SPO will continue to move forward not only due to potential commercial aviation economic benefits, but also because one day, technology will allow it and perhaps even demand it.