The purpose of this work is to gain a better understanding of the complex damage phenomena taking place at the railway wheel/brake block interface due to thermo-mechanical loading. Initially, full-stop braking was studied using Finite Element (FE) simulations to estimate the temperature reached in the wheel rim. Experiments to reproduce wheel damage were conducted with a two-disc machine using test conditions that were based on the results of the FE simulations. Three different wheel steels were tested against the same cast iron shoe material. The evolution of the wheel disc damage was studied at various numbers of cycles under fixed contact pressure and sliding speed. The friction coefficient and the temperature on the wheel disc surface were measured during the tests. At the end of the experiments, the wheel disc was examined and characterized. Cross-sections were observed with an optical microscope and the hardness was measured as a function of the depth to investigate the damage mechanisms that occurred at surface and subsurface. Material transfer from the shoe specimen to the wheel specimen results in the formation of a discontinuous “third body” layer, and that layer plays a key role in the evolution of the wheel disc damage. When the transferred layer of brake material is worn away, detachment of steel from the wheel disc surface occurs, probably promoting the crack nucleation. In addition, wear debris from both disc materials promotes three-body abrasive wear of the wheel disc surface. •The damage phenomena taking place at the wheel/brake block interface were investigated.•The temperature map in the wheel rim was estimated by thermal FE simulations.•Experimental tests were performed with a two-disc machine to reproduce the wheel damage.•The brake material transfer plays a key role in the wheel disc damage evolution.