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Robilliard, Bertrand; Arnaud, Erik; Gastaud, Lauris; Broner, Jonathan
European journal of cancer (1990), November 2018, 2018-11-00, 20181101, Letnik: 103Journal Article
Robilliard et al present a case of pembrolizumab-induced autoimmune haemolytic anaemia with polymyalgia rheumatica in a 79-year-old woman who was admitted for blood transfusion in a geriatric day hospital. The patient had been diagnosed with a choroidal melanoma discovered in 2011 and initially treated by proton therapy. In 2014, she had a complete removal of the eye. The follow-up showed evidence of hepatic metastasis in 2016 which led to four cycles of chemoembolisation. Checkpoint inhibitors are recent therapies against cancer, and their indications are currently undergoing rapid expansion. However, these treatments unleash immune activation that triggers potential autoimmune side-effects.
