Display omitted •Acetaldehyde is a volatile organic compound derived from natural and human resources and industry.•SEM, XRD, BET, EDX, and FTIR analyzes were used to determine the catalyst properties.•The removal efficiency increased with increasing temperature, time, catalyst dose, and decreasing pollutant concentration.•The highest degradation efficiency was 67% at 50 ppm, 30% relative humidity, and 35 °C after 120 minutes of irradiation.•The results showed that MIL100(Fe) is a successful catalyst for photocatalytic degradation of gaseous acetaldehyde. Increasing environmental pollution of human origin, especially air pollution, is one of the concerns of politicians in the past, present, and future, which has attracted attention to the processes developed to eliminate these pollutants and resolve the crisis. Acetaldehyde is a volatile organic compound derived from natural and human resources and industry. The present study aimed to evaluate the photocatalytic oxidation efficiency of MIL100(Fe) coated on glass under visible light irradiation for acetaldehyde removal. SEM, XRD, BET, EDX, and FTIR analyzes were used to determine the catalyst properties. The effect of parameters such as initial pollutant concentration, catalyst dose, temperature, time, and relative humidity was investigated. It was observed that the removal efficiency increased with increasing temperature, time, catalyst dose, and decreasing the input pollutant concentration. The highest degradation efficiency was 67% at 50 ppm, 30% relative humidity, and 35 °C after 120 min of irradiation. The results showed that MIL100(Fe) nanoparticles could be used as a successful catalyst in building materials, including glass, to reduce the amount of acetaldehyde and outher pollutant in indoor environments of homes and industries. This study highlights the need to remove acetaldehyde contaminants in gaseous media.