Analgesia and sedation are an integral part of the care provided to critically ill patients with COVID-19. These patients experience moderate to severe pain at rest and during standard care procedures. Objectives: The objective of this work is to identify the importance of sedation in patients hospitalized with COVID-19. Method: The Latin American and Caribbean Literature in Health Sciences (LILACS) and National Library of Medicine (MEDLINE) database were used to find scientific articles that were useful in clarifying this study. Results: An analysis and discussion of 5 experimental articles were carried out to fulfill the objective of this study. Conclusion: Regardless of the medications used, it is believed that it is essential that each ICU develop its management schemes for sedation, analgesia, delirium, mobility, and family involvement to achieve a consistent approach in the management of its patients and, thus, improve the clinical results.