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Förster, Anja, MSc; Blissenbach, Birgit, MSc; Machova, Alzbeta, BSc; Leja, Silke, MTA; Rabenhorst, Anja, PhD; Wilmschen, Sarah, MSc; Heger, Klaus, MSc; Schmidt-Supprian, Marc, PhD; Roers, Axel, MD; Hartmann, Karin, MD; Papadopoulou, Nikoletta, PhD
Journal of allergy and clinical immunology, 04/2015, Letnik: 135, Številka: 4Journal Article
...to these alterations in CTMCs, MMC numbers were comparable between Mcpt5Cre/Dicerfl/fl mice and Dicerfl/fl control animals, as indicated by unchanged serum levels of mMCP-1 (Fig 1, H) and comparable expression of Mcpt1 and Mcpt2 mRNA in the small intestine in both groups (Fig 1, I and J). Because MCs are major effector cells of anaphylaxis, we next sought to investigate the response of Mcpt5Cre/Dicerfl/fl mice in IgE-mediated passive systemic anaphylaxis (Fig 1, K). In line with our findings, Dicer ablation in vivo has been shown to also affect maturation of granulocyte/macrophage progenitors toward neutrophils, macrophages, and dendritic cells, as well as T-cell differentiation, B-cell development, and germinal center formation.2,8 Expression of Mcpt5Cre has previously been demonstrated to be highly specific for CTMCs,4 with the exception of TH2 cell-mediated expansion of MMCs.9 To further assess the specificity of Mcpt5Cre-mediated deletion of Dicer, we next analyzed the number of different myeloid and lymphoid cells in peripheral blood, the spleen, and the peritoneal cavity (Fig 2).
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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