E-viri
Recenzirano
Odprti dostop
-
Li, Ting; Rooij, Daan; Roth Mota, Nina; Buitelaar, Jan K.; Hoogman, Martine; Arias Vasquez, Alejandro; Franke, Barbara; Ambrosino, Sara; Banaschewski, Tobias; Bandeira, Cibele E.; Bau, Claiton H.D.; Baumeister, Sarah; Baur‐Streubel, Ramona; Bellgrove, Mark A.; Biederman, Joseph; Bramati, Ivanei E.; Berm, Silvia; Busatto, Geraldo F.; Calvo, Anna; Castellanos, Francisco X.; Chantiluke, Kaylita C.; Christakou, Anastasia; Coghill, David; Conzelmann, Annette; Cupertino, Renata B.; Zeeuw, Parick; Durston, Sarah; Earl, Eric A.; Epstein, Jeffery N.; Fallgatter, Andreas J.; Fair, Damien A.; Faraone, Stephen V.; Frodl, Thomas; Gabel, Matt C.; Gogberashvili, Tinatin; Grevet, Eugenio H.; Haavik, Jan; Hartman, Catharina A.; Heslenfeld, Dirk J.; Hoekstra, Pieter J.; Høvik, Marie F.; Jahanshad, Neda; Karkashadze, Georgii; Kelly, Clare; Kohls, Gregor; Konrad, Kerstin; Kuntsi, Jonna; Lazaro, Luisa; Lera‐Miguel, Sara; Lesch, Klaus‐Peter; Louza, Mario R.; Lundervold, Astri J.; McCarthy, Hazel; Nicolau, Rosa; Nigg, Joel T.; O'Gorman Tuura, Ruth L.; Oosterlaan, Jaap; Oranje, Bob; Paloyelis, Yannis; Pauli, Paul; Plessen, Kerstin J.; Ramos‐Quiroga, J. Antoni; Reif, Andreas; Reneman, Liesbeth; Rosa, Pedro G.P.; Rubia, Katya; Schrantee, Anouk; Schweren, Lizanne J.S.; Seitz, Jochen; Shaw, Philip; Silk, Tim J.; Skokauskas, Norbert; Carlos Soliva Vila, Juan; Soloveva, Anastasiia; Stevens, Michael C.; Sudre, Gustavo; Tamm, Leanne; Thompson, Paul M.; Tovar‐Moll, Fernanda; Erp, Theo GM; Vance, Alasdair; Vilarroya, Oscar; Vives‐Gilabert, Yolanda; Walitza, Susanne; Yoncheva, Yuliya N.; Zanetti, Marcus V.; Ziegler, Georg C.; Anikin, Anatoly; Asherson, Philip; Baranov, Alexandr; Chaim‐Avanicini, Tiffany; Dale, Anders M.; Doyle, Alysa E.; Jernigan, Terry; Kapilushniy, Dmitry; Mehta, Mitul; Namazova‐Baranova, Leyla; Novotny, Stephanie E.; Oberwelland Weiss, Eileen; Schwarz, Lena
Journal of child psychology and psychiatry, September 2021, Letnik: 62, Številka: 9Journal Article
Background Attention‐deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD’s etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. Methods Using the large ENIGMA‐ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. Results Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case–control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. Conclusions Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case–control differences appear more pronounced at least in some of the subgroups.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.