E-viri
Recenzirano
Odprti dostop
-
Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial developmentMincer, Sarah T.; Niethamer, Terren K.; Teng, Teng; Bush, Jeffrey O.; Percival, Christopher J.
Developmental dynamics, July 2022, Letnik: 251, Številka: 7Journal Article
Background: Variation in facial shape may arise from the combinatorial or overlapping actions of paralogous genes. Given its many members, and overlapping expression and functions, the EPH receptor family is a compelling candidate source of craniofacial morphological variation. We performed a detailed morphometric analysis of an allelic series of E14.5 Ephb1‐3 receptor mutants to determine the effect of each paralogous receptor gene on craniofacial morphology. Results: We found that Ephb1, Ephb2, and Ephb3 genotypes significantly influenced facial shape, but Ephb1 effects were weaker than Ephb2 and Ephb3 effects. Ephb2−/− and Ephb3−/− mutations affected similar aspects of facial morphology, but Ephb3−/− mutants had additional facial shape effects. Craniofacial differences across the allelic series were largely consistent with predicted additive genetic effects. However, we identified a potentially important nonadditive effect where Ephb1 mutants displayed different morphologies depending on the combination of other Ephb paralogs present, where Ephb1+/−, Ephb1−/−, and Ephb1−/−; Ephb3−/− mutants exhibited a consistent deviation from their predicted facial shapes. Conclusions: This study provides a detailed assessment of the effects of Ephb receptor gene paralogs on E14.5 mouse facial morphology and demonstrates how the loss of specific receptors contributes to facial dysmorphology. Key Findings Ephb1, Ephb2, and Ephb3 genotypes significantly influenced facial shape, but Ephb1 effects were weaker than Ephb2 and Ephb3 effects. Craniofacial differences across the allelic series were largely consistent with predicted additive genetic effects. Ephb1+/‐, Ephb1‐/‐, and Ephb1‐/‐; Ephb3‐/‐ mutants exhibited a consistent deviation from their predicted facial shapes. This study provides a detailed assessment of the effects of Ephb receptor gene paralogs on E14.5 mouse facial morphology and demonstrates how the combinatorial or overlapping actions of paralogous genes may influence facial shape variation.
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.