We examine how the shift toward intensive work-from-home during the Coronavirus disease (COVID-19) pandemic has impacted the experience of interruptions during work time. We conducted a two-wave survey of 249 employees working from home during the COVID-19 pandemic. Building on a conceptual framework and typology (Leroy et al., 2020), we examine changes in the prevalence of interruptions since-COVID-19 as a function of interruption type (intrusions, distractions, breaks, multitasking, and surprises), source (work-based vs. nonwork), and timing (pre- vs. since-COVID-19). We find a large increase in interruptions since-COVID, with the largest increases observed for nonwork intrusions, distractions, and multitasking. Women reported a greater increase in interruptions, particularly with regard to nonwork interruptions of all types, in addition to work-based intrusions, multitasking, and surprises, uncovering an important source of gender inequity. A dedicated unshared workspace at home was associated with fewer nonwork interruptions, while more nonwork responsibilities predicted more nonwork interruptions. Further differentiation of interruption types and sources was observed with regard to outcomes of interruptions. Nonwork interruptions predicted higher family-to-work interference, emotional exhaustion, and lower performance. Notably, these relationships varied meaningfully across specific interruption-type/outcome combinations, highlighting the value of differentiating interruptions by type. Work-based interruptions-especially intrusions and multitasking-were associated with higher work-family interference and emotional exhaustion, as well as lower performance. The results of this study provide valuable insights to help understand and, ultimately, improve work experiences in the midst of the COVID-19 pandemic while also contributing to the broader literatures on interruptions and remote work.