E-viri
Recenzirano
Odprti dostop
-
Crinion, Shane; Morris, Derek W.; Lopez, Lorna M.
Genes, brain and behavior, February 2024, Letnik: 23, Številka: 1Journal Article
Genome‐wide association studies (GWAS) have been important for characterizing the genetic component and enhancing our understanding of the biological aetiology of both neuropsychiatric disorders and sleep‐related phenotypes such as chronotype, which is our preference for morning or evening time. Mendelian randomization (MR) is a post‐GWAS analysis that is used to infer causal relationships between potential risk factors and outcomes. MR uses genetic variants as instrumental variants for exposures to study the effect on outcomes. This review details the main results from GWAS of neuropsychiatric disorders and sleep‐related phenotypes, and the application of MR to investigate their bidirectional relationship. The main results from MR studies of neuropsychiatric disorders and sleep‐related phenotypes are summarized. These MR studies have identified 37 causal relationships between neuropsychiatric disorders and sleep‐related phenotypes. MR studies identified evidence of a causal role for five neuropsychiatric disorders and symptoms (attention deficit hyperactivity disorder, bipolar disorder, depressive symptoms, major depressive disorder and schizophrenia) on sleep‐related phenotypes and evidence of a causal role for five sleep‐related phenotypes (daytime napping, insomnia, morning person, long sleep duration and sleep duration) on risk for neuropsychiatric disorders. These MR results show a bidirectional relationship between neuropsychiatric disorders and sleep‐related phenotypes and identify potential risk factors for follow‐up studies. Mendelian randomization (MR) uses genetic variants as instrumental variants for exposures e.g., chronotype (preference for morning or evening time) to investigate their causal relationship with an outcome e.g., schizophrenia (SCZ), under a number of assumptions. This review of MR studies summarises the bidirectional relationship between neuropsychiatric disorders and sleep‐related phenotypes.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.