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Zyuz’kov, G. N.; Zhdanov, V. V.; Miroshnichenko, L. A.; Polyakova, T. Yu; Stavrova, L. A.; Simanina, E. V.; Minakova, M. Yu; Agafonov, V. I.; Churin, A. A.
Bulletin of experimental biology and medicine, 09/2022, Letnik: 173, Številka: 5Journal Article
The psychopharmacological effects of a stimulator of functions of progenitor cells of the nervous tissue STAT3 inhibitor (STAT3 Inhibitor XIV, LLL12) were studied under conditions of modeled alcoholic encephalopathy in C57BL/6 mice. The pharmacological agent corrected the parameters of exploratory behavior (characterizing predominantly cognitive activity) in the experimental animals at the late terms of observation. At the same time, the reproducibility of the conditioned passive avoidance response developed at the beginning of the course STAT3 inhibitor administration decreased. These effects developed against the background of a significant increase in the content of neural stem cells and their proliferative activity in the paraventricular zone of the brain.
