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García-García, Amalia; Rojas, Sara; Rivas-García, Lorenzo; Navarro-Hortal, María D; Romero-Márquez, Jose M; Fernández-Bolaños, José G; Choquesillo-Lazarte, Duane; Salinas-Castillo, Alfonso; López, Óscar; Quiles, José L; Rodríguez-Diéguez, Antonio
Chemical communications (Cambridge, England), 2022-Feb-01, Letnik: 58, Številka: 10Journal Article
A new palladium coordination compound based on gliclazide with the chemical formula Pd(glz) (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the model, which has never been reported.
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in: SICRIS
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