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Šušnjara, Petar; Kolobarić, Nikolina; Matić, Anita; Mihaljević, Zrinka; Stupin, Ana; Marczi, Saška; Drenjančević, Ines
Frontiers in bioscience, 12/2022, Letnik: 27, Številka: 12Journal Article
Dietary supplementation with compounds that possess antioxidant and anti-inflammatory properties ( polyunsaturated fatty acids (PUFAs), selenium, vitamin E, lutein), has been shown to positively correlate with improvements in chronic conditions, although understanding of these combined effects in healthy humans is limited. The study aimed to evaluate the effects of enriched eggs consumption on oxidative status and inflammatory conditions in healthy volunteers. We hypothesized that a three-week diet containing enriched eggs can alter the immune response of healthy adults towards anti-inflammatory conditions. 34 participants consumed 3 hard-boiled hen eggs per day (21 days): Control group-regular hen eggs ( -3 PUFAs = 438 mg, selenium = 0.054 mg, lutein = 0.330 mg and vitamin E = 1.785 mg) ( = 14); 4Nutri group-hen eggs enriched with 4 nutrients ( PUFAs = 1026 mg, selenium = 0.06 mg, lutein = 1.85 mg and vitamin E = 3.29 mg) ( = 20). Samples were taken before and after the protocol. Serum concentrations of lipid mediators and cytokines were measured with enzyme-linked immunosorbent assay (ELISA) and antibody-based, magnetic bead reagent kits on the Luminex platform, respectively. Serum oxidative stress and antioxidant capacity were measured using standardized methods, while gene expression in peripheral blood mononuclear cells (PBMCs) was measured via real-time PCR. Decreased serum levels of pro-inflammatory interleukin 17A (IL-17A) and an increased neuronal nitric oxide synthase (nNOS) expression in the 4Nutri group, together with alteration of metabolites produced via cyclooxygenase (COX) pathways in the Control group, suggest a shift towards anti-inflammatory conditions in participants who consumed enriched hen eggs. Present results suggest that the combined action of PUFAs and antioxidants may have a protective role in resting, non-inflammatory conditions. NCT04564690.
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