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Kuri-Cervantes, Leticia; Pampena, M Betina; Meng, Wenzhao; Rosenfeld, Aaron M; Ittner, Caroline A G; Weisman, Ariel R; Agyekum, Roseline S; Mathew, Divij; Baxter, Amy E; Vella, Laura A; Kuthuru, Oliva; Apostolidis, Sokratis A; Bershaw, Luanne; Dougherty, Jeanette; Greenplate, Allison R; Pattekar, Ajinkya; Kim, Justin; Han, Nicholas; Gouma, Sigrid; Weirick, Madison E; Arevalo, Claudia P; Bolton, Marcus J; Goodwin, Eileen C; Anderson, Elizabeth M; Hensley, Scott E; Jones, Tiffanie K; Mangalmurti, Nilam S; Luning Prak, Eline T; Wherry, E John; Meyer, Nuala J; Betts, Michael R
Science immunology, 07/2020, Letnik: 5, Številka: 49Journal Article
Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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