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Habib, Naomi; McCabe, Cristin; Medina, Sedi; Varshavsky, Miriam; Kitsberg, Daniel; Dvir-Szternfeld, Raz; Green, Gilad; Dionne, Danielle; Nguyen, Lan; Marshall, Jamie L; Chen, Fei; Zhang, Feng; Kaplan, Tommy; Regev, Aviv; Schwartz, Michal
Nature neuroscience, 06/2020, Letnik: 23, Številka: 6Journal Article
The role of non-neuronal cells in Alzheimer's disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer's disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors.
