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Busscher, Henk J; van der Mei, Henny C; Subbiahdoss, Guruprakash; Jutte, Paul C; van den Dungen, Jan J A M; Zaat, Sebastian A J; Schultz, Marcus J; Grainger, David W
Science translational medicine, 2012-Sep-26, Letnik: 4, Številka: 153Journal Article
Biomaterial-associated infections occur on both permanent implants and temporary devices for restoration or support of human functions. Despite increasing use of biomaterials in an aging society, comparatively few biomaterials have been designed that effectively reduce the incidence of biomaterial-associated infections. This review provides design guidelines for infection-reducing strategies based on the concept that the fate of biomaterial implants or devices is a competition between host tissue cell integration and bacterial colonization at their surfaces.
