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Gherardin, Nicholas A; Redmond, Samuel J; McWilliam, Hamish E G; Almeida, Catarina F; Gourley, Katherine H A; Seneviratna, Rebecca; Li, Shihan; De Rose, Robert; Ross, Fiona J; Nguyen-Robertson, Catriona V; Su, Shian; Ritchie, Matthew E; Villadangos, Jose A; Moody, D Branch; Pellicci, Daniel G; Uldrich, Adam P; Godfrey, Dale I
Science immunology, 06/2021, Letnik: 6, Številka: 60Journal Article
CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool. However, the study of CD1c-restricted T cells is hampered by the presence of an abundantly expressed, non-T cell receptor (TCR) ligand for CD1c on blood cells, confounding analysis of TCR-mediated CD1c tetramer staining. Here, we identified the CD36 family (CD36, SR-B1, and LIMP-2) as ligands for CD1c, CD1b, and CD1d proteins and showed that CD36 is the receptor responsible for non-TCR-mediated CD1c tetramer staining of blood cells. Moreover, CD36 blockade clarified tetramer-based identification of CD1c-restricted T cells and improved identification of CD1b- and CD1d-restricted T cells. We used this technique to characterize CD1c-restricted T cells ex vivo and showed diverse phenotypic features, TCR repertoire, and antigen-specific subsets. Accordingly, this work will enable further studies into the biology of CD1 and human CD1-restricted T cells.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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