Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids

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Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids

Obeng, Samuel; Kamble, Shyam H; Reeves, Morgan E; Restrepo, Luis F; Patel, Avi; Behnke, Mira; Chear, Nelson J-Y; Ramanathan, Surash; Sharma, Abhisheak; León, Francisco; Hiranita, Takato; Avery, Bonnie A; McMahon, Lance R; McCurdy, Christopher R

Journal of medicinal chemistry, 01/2020, Letnik: 63, Številka: 1

Journal Article

Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding, and metabolic stability. Mitragynine, the major alkaloid in (kratom), had higher affinity at opioid receptors than at adrenergic receptors while the vice versa was observed for corynantheidine. The observed polypharmacology of kratom alkaloids may support its utilization to treat opioid use disorder and withdrawal.

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Leto	Faktor vpliva		Izdaja		Kategorija		Razvrstitev
Leto	JCR	SNIP	JCR	SNIP	JCR	SNIP	JCR	SNIP

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