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  • Factors associated with nonadherence to thiopurines in adolescent and adult patients with inflammatory bowel disease
    Kamperidis, N; Goodhand, J R; Chowdhury, F A; Koodun, Y; Direzke, N C; Naik, S; Sanderson, I R; Croft, N M; Langmead, F L; Irving, P M; Rampton, D S; Lindsay, J O

    Journal of pediatric gastroenterology and nutrition 54, Številka: 5
    Journal Article

    We hypothesised that nonadherence to thiopurines is more common in adolescents than in adults with inflammatory bowel disease. We sought factors associated with thiopurine nonadherence defined by thiopurine metabolite levels. Multivariate logistic regression confirmed that adolescents (odds ratio OR 4.6 95% confidence interval CI 1.9-11.5; P < 0.01) compared with adults, patients with Crohn disease (OR 3.3 CI 1.1-10.5 P = 0.04) compared with ulcerative colitis, and patients living in more socially deprived areas (OR 1.03 CI 1.0-1.1 P = 0.02) were more likely to be nonadherent to thiopurines. Adolescents are more frequently nonadherent than adults: prospective studies are required to determine the reasons for nonadherence in adolescents.

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