...Hindle and Moroz (2010) asserted (based on Schnarch, 2004) that Indigenous research requires “methodologies … built upon frameworks grounded within long standing Indigenous knowledge management techniques, ensuring ownership, control, access and possession” (p. 376). Within this context, we conceived of a special issue that would focus on Indigenous knowledge and research methodologies, and encourage authors to critically reflect on the processes and activities of qualitative research in Indigenous contexts, Indigenous approaches to research design and implementation, and/or the challenges and opportunities resulting from Indigenous research strategies, with the objective of reconceptualizing current approaches to qualitative research through an Indigenous lens. ...Colbourne et al. present a case study that suggests how the strengths of western and Indigenous knowledge systems might be combined to advance research goals and facilitate reconciliation in Canada.