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Wang, Chenggang; Zhou, Mingqi; Zhang, Xudong; Yao, Jin; Zhang, Yanping; Mou, Zhonglin
eLife, 07/2017, Letnik: 6Journal Article
Nicotinamide adenine dinucleotide (NAD ) participates in intracellular and extracellular signaling events unrelated to metabolism. In animals, purinergic receptors are required for extracellular NAD (eNAD ) to evoke biological responses, indicating that eNAD may be sensed by cell-surface receptors. However, the identity of eNAD -binding receptors still remains elusive. Here, we identify a lectin receptor kinase (LecRK), LecRK-I.8, as a potential eNAD receptor in . The extracellular lectin domain of LecRK-I.8 binds NAD with a dissociation constant of 436.5 ± 104.8 nM, although much higher concentrations are needed to trigger in vivo responses. Mutations in inhibit NAD -induced immune responses, whereas overexpression of enhances the response to NAD . Furthermore, is required for basal resistance against bacterial pathogens, substantiating a role for eNAD in plant immunity. Our results demonstrate that lectin receptors can potentially function as eNAD -binding receptors and provide direct evidence for eNAD being an endogenous signaling molecule in plants.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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