Energy drinks have been anecdotally associated with deleterious cardiovascular health outcomes. These drinks contain ingredients which could affect glycemic response to the carbohydrate content. The aim of this study was to determine if acute exercise would alter the glycemic and physiological response to the consumption of Monster Energy. Following an overnight fast, human subjects (19.1 ± 1.4 years; 30 female; 5 male) were randomized to exercise on a stationary bike at 33% of their predicted VO2 max for 10 minutes with a five minute sitting rest after, or sitting (control) for 15 minutes prior to ingestion of Monster Energy. Blood glucose, heart rate, and blood pressure were measured 0-, 30-, 60-, and 90-minutes postprandially. Data is represented as LSM ± SE with significance analyzed using a t-test, or multiple comparison test (P < 0.05). Blood glucose (mg/dL) for control at 0-, 30-, 60-, and 90-minutes 91.5 ± 1.2, 133.7 ± 4.3, 96.3 ± 4.2, and 82.4 ± 1.8 mg/dL, respectively. For those receiving bike exercise prior to ingestion blood glucose was 92.2 ± 1.2, 126.6 ± 3.8, 92.5 ± 2.3, 84.0 ± 1.8 mg/dL. Within group significance in both groups was observed between 0 and 30, 30 and 60, and 60 and 90, for control only, there were no significant blood glucose differences observed between groups across time. Heart rate for control at 0-, 30-, 60-, and 90-minutes was 78.0 ± 3.1, 78.2 ± 2.5, 78.6 ± 2.6, and 74.4 ± 1.9 respectively. For those receiving bike exercise prior to ingestion heart rate was 88.7 ± 3.71, 85.5 ± 2.7, 83.1 ± 2.3, and 80.3 ± 2.9, with significance between 0 and 90 minutes. Mean arterial blood pressure for control at 0-, 30-, 60-, and 90-minutes was 86.8 ± 2.6, 89.2 ± 2.1, 89.2 ± 2.5, and 87.6 ± 2.6. For those receiving bike exercise prior to ingestion blood pressure was 90.6 ± 3.1, 88.98 ± 2.3, 88.2 ± 2.0, and 87.0 ± 2.9 with no significant differences. Exercise probably does not alter the glycemic and physiological response to energy drinks. WSU Biology Department.