UP - logo
E-viri
Celotno besedilo
Recenzirano
  • PFK-2/FBPase-2: maker and b...
    Okar, David A.; Lange, Alex J.; Manzano, Ànna; Navarro-Sabatè, Aurèa; Riera, Lluı̀s; Bartrons, Ramon

    Trends in Biochemical Sciences, 2001, 2001-Jan, 2001-1-00, 20010101, Letnik: 26, Številka: 1
    Book Review, Journal Article

    Fructose-2,6-bisphosphate is responsible for mediating glucagon-stimulated gluconeogenesis in the liver. This discovery has led to the realization that this compound plays a significant role in directing carbohydrate fluxes in all eukaryotes. Biophysical studies of the enzyme that both synthesizes and degrades this biofactor have yielded insight into its molecular enzymology. Moreover, the metabolic role of fructose-2,6-bisphosphate has great potential in the treatment of diabetes.