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Miller, John F.; Turner, Elizabeth M.; Gudmundsson, Kristjan S.; Jenkinson, Stephen; Spaltenstein, Andrew; Thomson, Michael; Wheelan, Pat
Bioorganic & medicinal chemistry letters, 04/2010, Letnik: 20, Številka: 7Journal Article
The lead optimization of a series of N-substituted benzimidazole CXCR4 antagonists is described. Side chain modifications and stereochemical optimization led to substantial improvements in potency and protein shift to afford compounds with low nanomolar anti-HIV activity. The lead optimization of a series of N-substituted benzimidazole CXCR4 antagonists is described. Side chain modifications and stereochemical optimization led to substantial improvements in potency and protein shift to afford compounds with low nanomolar anti-HIV activity.
