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Mikleušević, Ana; Hameršak, Zdenko; Salopek-Sondi, Branka; Tang, Lixia; Janssen, Dick B.; Majerić Elenkov, Maja
Advanced synthesis & catalysis, May 26, 2015, Letnik: 357, Številka: 8Journal Article
An efficient dynamic kinetic resolution protocol using a single enzyme is described. Both the kinetic resolution and substrate racemization are catalyzed by halohydrin dehalogenase from Agrobacterium radiobacter AD1 (HheC). The HheC‐catalyzed reaction of epibromohydrin and 2‐bromomethyl‐2‐methyloxirane with sodium cyanate afforded 5‐substituted 2‐oxazolidinones in high yields (97% and 87%) and high optical purity (89% and >99% ee) in the presence of catalytic amounts of bromide ion. These compounds are valuable building blocks with diverse synthetic applications.
