In the context of the Korean Peninsula, North Gyeongsang Province stands out as a focal point for increased seismic activity, housing notable nuclear power plants (NPPs) such as Hanul and Wolseong. This study meticulously undertook an assessment of seismic hazard, ground response, and liquefaction potential specific to the North Gyeongsang region. These multifaceted evaluations served as foundational components intricately interwoven to construct an advanced microzonation map. The genesis of this microzonation map is tied to the Seismic Hazard Index ((Sindex), a sophisticated framework discerning sites in the southern and southeastern regions, including Pohang, Yeongdeok, Bulguksa, and Yangdong Folk Village, as predisposed to an elevated seismic threat. A noteworthy observation noted as both aforementioned NPPs fall within this identified zone of intense seismic vulnerability. The microzonation outcomes laid the groundwork for a thorough examination of the seismic vulnerability inherent to NPPs. This scrutiny, in turn, facilitated the derivation of intricate risk matrices, serving as a cornerstone in the structure of comprehensive risk assessment. Broadening the scope, a dedicated seismic risk assessment was executed specifically for the Wolseong NPP. The results of this assessment are presented artfully across three distinct post-earthquake functional scenarios, achieved through the integration of a meticulously derived site-specific intensity-response relationship for assumed damage states. Simultaneously, the exposure of health, safety, and operational risks for each damage state enriched the narrative. This study provided the foundational elements intricately woven together to craft the inaugural advanced microzonation map for North Gyeongsang in South Korea. This entire compendium serves as a first guiding, shedding light on the pathway toward the pioneering development of earthquake-resistant designs for NPPs in South Korea. •Microzonation map by assessing seismic hazard and liquefaction potential.•Seismic risk assessment for the Wolseong Nuclear Power Plant using risk matrices.•Health, safety, and operational risks for Wolseong Nuclear Power Plant.•Functionality mappings will be useful for evaluating future Nuclear Power Plants.