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Singh, Fateh V.; Vatsyayan, Rit; Roy, Uma; Goel, Atul
Bioorganic & medicinal chemistry letters, 05/2006, Letnik: 16, Številka: 10Journal Article
A series of anthranilodinitrile-based biaryls were synthesized and evaluated in vitro against extracellular promastigotes and intracellular amastigotes of Leishmania donovani. Among various screened compounds, a biaryl with trifluoromethyl group 5f showed 83% inhibition against promastigotes and 70% inhibition against amastigotes of L. donovani at 8 and 20μg/mL concentrations, respectively.
