2D metal‐organic frameworks‐based (2D MOF‐related) materials benefit from variable topological structures, plentiful open active sites, and high specific surface areas, demonstrating promising applications in gas storage, adsorption and separation, energy conversion, and other domains. In recent years, researchers have innovatively designed multiple strategies to avoid the adverse effects of conventional methods on the synthesis of high‐quality 2D MOFs. This review focuses on the latest advances in creative synthesis techniques for 2D MOF‐related materials from both the top‐down and bottom‐up perspectives. Subsequently, the strategies are categorized and summarized for synthesizing 2D MOF‐related composites and their derivatives. Finally, the current challenges are highlighted faced by 2D MOF‐related materials and some targeted recommendations are put forward to inspire researchers to investigate more effective synthesis methods. Two strategies, top‐down and bottom‐up, are used to explore the various synthesis approaches for the 2D metal‐organic framework (MOF)‐related materials. Top‐down method includes sonication exfoliation, moderate physical exfoliation, electrochemical exfoliation, chemical intercalation, and Alkali‐etching exfoliation. Bottom‐up method includes modulation synthesis, interface synthesis, template assistance and sacrifice, and surfactant‐assisted synthesis. This review also summarizes other synthesis methods.