E-viri
Recenzirano
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Yang, Yunxia; Sun, Xiaqing; Zhao, Yang; Ge, Wenhao; Ding, Zhao; Liu, Junhao; Wang, Lei; Xu, Xi; Zhang, Jianfa
Carbohydrate polymers, 03/2021, Letnik: 255Journal Article
Display omitted •Riclin is confirmed as a succinoglycan via methylation and NMR analysis.•Riclin and cyclophosphamide have comparable efficiency in inhibiting sarcoma growth.•Riclin promotes lymphocytes proliferation significantly in vivo.•Riclin decreases splenocytes apoptosis and alters splenocytes metabolic profiling. Natural polysaccharides have attracted considerable interests due to diverse biological activities. Succinoglycan is an extracellular polysaccharide produced by most Agrobacterium strains. Here, we confirmed riclin was a typical succinoglycan by NMR and methylation analysis, and investigated the antitumor effects of riclin in sarcoma 180 tumor-bearing mice. The results showed that riclin inhibited the tumor growth significantly as well as cyclophosphamide (CTX). While CTX caused serious damage to spleen structure, riclin increased the spleen index and promoted lymphocytes proliferation in peripheral blood, spleen and lymph nodes. Riclin decreased splenocytes apoptosis as evidenced by alterations of B-cell lymphoma-2 family proteins and Cleaved Caspase-3 protein. Moreover, 1H nuclear magnetic resonance (NMR)-based metabolomics analysis revealed that riclin partially altered the metabolic profiles of splenocytes. In conclusion, riclin is a succinoglycan that performed strong immunogenicity and suppressed sarcoma growth in mice. Succinoglycan riclin could be a potential antitumor agent for functional food and pharmaceutical purpose.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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