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Swenson, Samantha A; Moore, Courtney M; Marcero, Jason R; Medlock, Amy E; Reddi, Amit R; Khalimonchuk, Oleh
Cells (Basel, Switzerland), 02/2020, Letnik: 9, Številka: 3Journal Article
Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme-a highly reactive and inherently toxic compound-and its subsequent delivery to target proteins remain far from clear. In this review, we summarize current knowledge about heme biosynthesis and trafficking within and outside of the mitochondria.
