Echinochloa crus-galli (L.) P. Beauv. is the most common monocotyledonous weed in maize crops in Croatia. Crop–weed interference is influenced by weed emergence patterns, and knowledge of the timing of weed emergence is crucial for the development of an efficient integrated weed-management program. Therefore, two-year field experiments were conducted in a maize crop sown in early May in continental Croatia to determine the emergence pattern of E. crus-galli from natural seedbank. In laboratory studies, the estimated base temperature and base water potential for the Croatian ecotype of E. crus-galli were 10.8 °C and −0.97 MPa, respectively. Then, the estimated germination parameters were compared with the values embedded in the AlertInf model from Italy (Veneto) to calibrate this hydrothermal model. The estimated hydrothermal units were around 28 for the onset (10%) and 93 for the middle (50%) emergence of E. crus-galli. Our findings showed that the AlertInf model satisfactorily simulated the emergence of E. crus-galli in maize crop in Croatia (EF = 0.97 in 2019 and 0.98 in 2020), indicating its potential use in other geographical areas