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Liegeois, Maude; Legrand, Celine; Desmet, Christophe J.; Marichal, Thomas; Bureau, Fabrice
Cellular immunology, 08/2018, Letnik: 330Journal Article, Web Resource
•Lung interstitial macrophages have long been ignored by scientists.•Lung interstitial macrophages are ontogenically distinct from alveolar macrophages.•Lung interstitial macrophages exert unique immunoregulatory activities. Lung macrophages have mostly been studied considering only their most accessible and well-defined representative, the alveolar macrophage (AM). In contrast, the identity and putative immune functions of their tissue counterpart, the interstitial macrophage (IM), have long remained much more elusive. Yet, recent evidence supports the notion that IMs perform important immune functions in the lung, notably in terms of innate immunoregulation. Here, we review current knowledge on the phenotype, ontogeny and function of IMs and propose strategies for the unambiguous identification and study of this important and dynamic lung innate immune cell population.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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