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Simeone, Regina M.; Zambrano, Laura D.; Halasa, Natasha B.; Fleming-Dutra, Katherine E.; Newhams, Margaret M.; Wu, Michael J.; Orzel-Lockwood, Amber O.; Kamidani, Satoshi; Pannaraj, Pia S.; Irby, Katherine; Maddux, Aline B.; Hobbs, Charlotte V.; Cameron, Melissa A.; Boom, Julie A.; Sahni, Leila C.; Kong, Michele; Nofziger, Ryan A.; Schuster, Jennifer E.; Crandall, Hillary; Hume, Janet R.; Staat, Mary A.; Mack, Elizabeth H.; Bradford, Tamara T.; Heidemann, Sabrina M.; Levy, Emily R.; Gertz, Shira J.; Bhumbra, Samina S.; Walker, Tracie C.; Bline, Katherine E.; Michelson, Kelly N.; Zinter, Matt S.; Flori, Heidi R.; Campbell, Angela P.; Randolph, Adrienne G.; Colston, Candice; Kelley, Heather; Murdock, Meghan; Miron, Laura; Sanders, Ronald C.; Hakimi, Daniel; Jumarang, Jaycee; Mrotek, Kennis-Grace; Niell, Liria Muriscot; Baig, Natasha; Petruccelli, Lexi; Sierra, Yamila; Temte, Elizabeth; Thayer, Imogene; Zorensky, Frances; Baida, Nadine; Choi, Jong-Ha C.; Ciric, Caroline R.; Gonzalez, Mark D.; Coates, Bria M.; Price, Heather E.; Stumpf, Mary; Clark, Maya; Dittrich, Rylie; Kucukak, Suden; Listerud, Eve; Moran, Patrick; Drapeau, Noelle M.; Johnson, Brandi A.; Malloch, Lacy; Martin, Lora; Martin, Maygan; Patterson, Kayla; Sanders, Cameron; Pruitt, Shannon; Kansas City, Children’s Mercy; Sullivan, Melissa; Schwartz, Stephanie P.; Tomcany, Merry; Rohlfs, Chelsea C.; Wolfe, Amber; Mohammed, Fatima A.; Reed, J. Nelson; Rusler, Zachary; Thomas, Jack; Wakser, Cayla; Fernandez, Kailee; Stewart, Laura S.; Abojaib, Leenah; Kyles, Molly J.
MMWR. Morbidity and mortality weekly report, 09/2023, Letnik: 72, Številka: 39Journal Article
Infants aged <6 months are not eligible for COVID-19 vaccination. Vaccination during pregnancy has been associated with protection against infant COVID-19-related hospitalization. The Overcoming COVID-19 Network conducted a case-control study during March 9, 2022-May 31, 2023, to evaluate the effectiveness of maternal receipt of a COVID-19 vaccine dose (vaccine effectiveness VE) during pregnancy against COVID-19-related hospitalization in infants aged <6 months and a subset of infants aged <3 months. VE was calculated as (1 - adjusted odds ratio) x 100% among all infants aged <6 months and <3 months. Case-patients (infants hospitalized for COVID-19 outside of birth hospitalization and who had a positive SARS-CoV-2 test result) and control patients (infants hospitalized for COVID-19-like illness with a negative SARS-CoV-2 test result) were compared. Odds ratios were determined using multivariable logistic regression, comparing the odds of receipt of a maternal COVID-19 vaccine dose (completion of a 2-dose vaccination series or a third or higher dose) during pregnancy with maternal nonvaccination between case- and control patients. VE of maternal vaccination during pregnancy against COVID-19-related hospitalization was 35% (95% CI = 15%-51%) among infants aged <6 months and 54% (95% CI = 32%-68%) among infants aged <3 months. Intensive care unit admissions occurred in 23% of all case-patients, and invasive mechanical ventilation was more common among infants of unvaccinated (9%) compared with vaccinated mothers (1%) (p = 0.02). Maternal vaccination during pregnancy provides some protection against COVID-19-related hospitalizations among infants, particularly those aged <3 months. Expectant mothers should remain current with COVID-19 vaccination to protect themselves and their infants from hospitalization and severe outcomes associated with COVID-19.
