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  • Integration of Bromine and ...
    Glotz, Gabriel; Lebl, René; Dallinger, Doris; Kappe, C. Oliver

    Angewandte Chemie International Edition, October 23, 2017, Letnik: 56, Številka: 44
    Journal Article

    A continuous‐flow process for the in situ on‐demand generation of cyanogen bromide (BrCN) from bromine and potassium cyanide that makes use of membrane‐separation technology is described. In order to circumvent the handling, storage, and transportation of elemental bromine, a continuous bromine generator using bromate–bromide synproportionation can optionally be attached upstream. Monitoring and quantification of BrCN generation was enabled through the implementation of in‐line FTIR technology. With the Br2 and BrCN generators connected in series, 0.2 mmol BrCN per minute was produced, which corresponds to a 0.8 m solution of BrCN in dichloromethane. The modular Br2/BrCN generator was employed for the synthesis of a diverse set of biologically relevant five‐ and six‐membered cyclic amidines and guanidines. The set‐up can either be operated in a fully integrated continuous format or, where reactive crystallization is beneficial, in semi‐batch mode. Cyanogen bromide on tap: The highly toxic but synthetically powerful reagent cyanogen bromide (BrCN) was generated in a fully continuous fashion from benign precursors and directly used for the synthesis of medicinally relevant N‐heterocycles.