Since the drainage would be performed by opening a pericardial window with mini-thoracotomy from the left midclavicular 5th intercostal space, we performed the transversus thoracic muscle plane (TTMP) block in combination with the serratus anterior plane (SAP) block, which can effectively block this intervention area. In TTMP block, the blockade of intercostal nerves originated from T2–6 is targeted. ...it acts as a complementary block for the region medial to the midaxillary line. More randomized clinical trials are needed to evaluate the effectiveness of plane blocks in surgical procedures such as drainage of the pericardial tamponate.Funding The authors have no sources of funding to declare for this manuscript.Declaration of Competing Interest The authors declare no conflicts of interest.