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Lasseur, Catherine; Allen, Alice C.; Deminière, Colette; Aparicio, Michel; Feehally, John; Combe, Christian
American journal of kidney diseases, 02/1997, Letnik: 29, Številka: 2Journal Article
Abnormalities of immunoglobulin Al (IgAl) glycosylation have been described in patients with IgA nephropathy (IgAN), whether primitive or secondary to Henoch-Schönlein purpura. The Wiskott-Aldrich syndrome, an X-linked recessive disorder, is associated with abnormalities of IgA. Renal involvement with mesangial IgA deposition identical to that found in IgAN has been reported during this affection. We report the case of a female carrier of the Wiskott-Aldrich syndrome presenting with Henoch-Schönlein purpura and abnormalities of IgA glycosylation, as previously reported in patients with IgAN. The galactosylation abnormalities of IgA could be linked to the patient's status as carrier of the Wiskott-Aldrich syndrome and could contribute to the pathogenesis of IgAN.
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