OBJECTIVE: To compare the effects of neck exercises (McKenzie extension and isometric exercises) in the management of non-specific neck pain and range of motion in patients with neck pain. METHODS: This randomized controlled trial was conducted in physiotherapy departments of Dr. Akbar Niazi Teaching Hospital, Islamabad. Forty consecutive patients with acute to sub-acute cases of neck pain (<3 month) were enrolled. Based on lottery method two groups (n=20 in each group) were differentiated, Group-I (control) received isometric neck exercises and Group-II (treatment) received McKenzie extension exercises for 4-weeks along with hot packs therapy. Neck pain was measured using numeric pain rating scale (NPRS). All patients were tested on baseline, at 2nd and 4th week. RESULTS: Mean age of the sample was 33.85±4.80 and 33.50±5.20 years in group-I and group-II respectively. Male to female ratio was 4:1 in both groups. Mean body mass index was 24.54±1.50kg/m2. NPRS at baseline was 5.80±0.41 in group-I while 6.10±0.64 in group-II (p-value=0.001). NPRS decreased to 3.75±0.72 in group-I and 3.00±0.73 in group-II after 4-weeks (p-value=0.001). Neck flexion (degrees) at baseline was 31±2.05 in group-I and 35.75±1.83 in group-II (p-value=0.001) while after 4weeks increased to 35.50±4.26 in group-I and 40±4.29 in group-II (p-value=0.002). Neck extension (degrees) at baseline was 44±2.05 in group-I and 40.75±1.83 in group-II (p-value=0.001) while after 4-weeks increased to 48.5±4.01 in group-I and 45±4.29 in group-II (p-value=0.011). CONCLUSION: McKenzie exercises are more significant and show more improvement in reduction of pain and associated symptoms of neck and increased movements quicker than isometric exercises.